Journal: bioRxiv

Article Title: MOLECULAR CORRELATE OF MOUSE EXECUTIVE FUNCTION. TOP-DOWN AND BOTTOM-UP COMPLEMENTATIONS BY PRESYNAPTIC VERTEBRATE BRAIN-SPECIFIC Ntng GENE PARALOGS

doi: 10.1101/139444

Figure Lengend Snippet: A,E. Mouse ranks and rank PVE (proportion of variance explained) based on four parameter rank measures (SF1) as detailed in ST1-1 (for Ntng1 -/- ) and ST1-2 (for Ntng2 -/- ). The rank sorting was done in a genotype-independent manner treating all micetogether. Ranking for each out of four parameters was done independently of other parameters with afinal re-ranking of the ranks sum to generate the final rank (shown). In case of an equal sum of the ranks, the mice were given identical ranks. PVE was calculated as a square of within genotype rank variance divided on the sum of each genotype variances squares multiplied on 100%. B,F . Mouse rank distribution across one-to-four parameters as top 4 and bottom 4 performers. C,G . Genotype-specific placing among the mice. D,H . Behavioral consistency of mice across the sessions ( y axis, sum of r 2 correlations of a single session ranks vs. final ranks for each mouse across the sessions) and behavioral parameter cross-correlations ( x axis, the r 2 correlation of a parameter final ranking vs . final ranking for all 4 parameters). The gene ablation-specific phenotype severity can be assessed visually by matching each parameter-corresponding verteces of the obtained quadruples. p value represents a Wilcoxon rank sum test.

Article Snippet: Wilcoxon rank sum test was done by Matlab (v.7.9.0 2009b) by the function ranksum .

Techniques:

Journal: bioRxiv

Article Title: MOLECULAR CORRELATE OF MOUSE EXECUTIVE FUNCTION. TOP-DOWN AND BOTTOM-UP COMPLEMENTATIONS BY PRESYNAPTIC VERTEBRATE BRAIN-SPECIFIC Ntng GENE PARALOGS

doi: 10.1101/139444

Figure Lengend Snippet: A,E . Mouse ranks and rank PVE (proportion of variance explained) based on four parameter rank measures (SF2) as detailed in ST2-1 (for Ntng1 -/- ) and ST2-2 (for Ntng2 -/- ). The rank sorting was done in a genotype-independent manner treating all mice together. Ranking for each out of four parameters was done independently of other parameters with a final re-ranking of the ranks sum to generate the final rank (shown). In case of an equal sum of the ranks, the mice were given identical ranks. PVE was calculated as a square of within genotype rank variance divided on the sum of each genotype variances squares multiplied on 100%. B,F . Mice rank distribution across one-to-four parameters as top 4 and bottom 4 performers. C,G . Genotype-specific placing among the mice. D,H . Behavioral consistency of mice across the sessions ( y axis, sum of r 2 correlations of a single session ranks vs . final ranks for each mouse across the sessions) and behavioral parameter cross-correlations ( x axis, the r 2 correlation of a parameter final ranking vs . final ranking for all 4 parameters). The gene ablation-specific phenotype severity can be assessed visually by matching each parameter-corresponding vertexes of the obtained quadruples. p value represents a Wilcoxon rank sum test.

Article Snippet: Wilcoxon rank sum test was done by Matlab (v.7.9.0 2009b) by the function ranksum .

Techniques:

Journal: bioRxiv

Article Title: MOLECULAR CORRELATE OF MOUSE EXECUTIVE FUNCTION. TOP-DOWN AND BOTTOM-UP COMPLEMENTATIONS BY PRESYNAPTIC VERTEBRATE BRAIN-SPECIFIC Ntng GENE PARALOGS

doi: 10.1101/139444

Figure Lengend Snippet: A . Learning curves for the operant conditioning learning (reward collection) over the training period (spatial 1 of 5-CSRTT) with averaged performance behavior for the days (1-7) and (8-14), middle panel, defined as low cognitive demand (LCD) and high cognitive demand (HCD) sessions, respectively. One and two-way ANOVA was used for the statistics. B . Ranks and PVE comparisons over the LCD and HCD. The rank sorting was done in a genotype-independent manner, similar to and , but using only one parameter, success (Sc), see ST2-1 and ST2-2 (Ln). Rank statistics was by Wilcoxon rank sum test. C . Learning (Ln) vs . attention and impulsivity (AI) rank correlations (from , ).

Article Snippet: Wilcoxon rank sum test was done by Matlab (v.7.9.0 2009b) by the function ranksum .

Techniques: